Investigation of Critical Core Formulation and Process Parameters for Osmotic Pump Oral Drug Delivery
نویسندگان
چکیده
منابع مشابه
Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac
BACKGROUND The osmotic drug delivery systems suitable for oral administration typically consist of a compressed tablet core that is coated with a semipermeable membrane that has an orifice drilled on it by means of a laser beam or mechanical drill. Ketorolac is a nonsteroidal agent with powerful analgesic. Oral bioavailability of ketorolac was reported to be 90% with very low hepatic first-pass...
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A novel elementary osmotic pump tablet was developed. The system uses the core of drug-resin complexes (DRCs) loaded with propranolol hydrochloride (PNH) for time-controlled delivery. In traditional osmotic pump tablets (OPTs), the lag time was always minimized. However, in the DRCs osmotic pump tablet (DRCOPT), the lag time was increased to achieve the time-controlled delivery. The quantity of...
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Swellable-core technology (SCT) formulations that used osmotic pressure and polymer swelling to deliver drugs to the GI tract in a reliable and reproducible manner were studied. The SCT formulations consisted of a core tablet containing the drug and a water-swellable component, and one or more delivery ports. The in vitro and in vivo performance of two model drugs, tenidap and sildenafil, formu...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2013
ISSN: 1530-9932
DOI: 10.1208/s12249-013-0040-4